Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of Tat proteins and Tat mutants of different human immunodeficiency virus type 1 clades on glial JC virus early and late gene transcription.

The Journal of general virology - 1 Mar 2013

Wright Clayton A, Nance Jonas A, Johnson Edward M

Abstract excerpt

Polyomavirus JC (JCV) is the aetiological agent of progressive multifocal leukoencephalopathy (PML), a frequently fatal infection of the brain afflicting nearly 4% of AIDS patients in the USA. Human immunodeficiency virus type 1 (HIV-1) Tat, acting together with cellular proteins at the JCV non-coding control region (NCCR), can stimulate JCV DNA transcription and replication. Tat in the brain is secreted by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Viral
Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Products, tat

Share to JC Virus

Share to Neuroglia

Share to Smad4 Protein

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 23152365
DOI: 10.1099/vir.0.047902-0
PMCID: PMC3709611

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of Tat proteins and Tat mutants of different human immunodeficiency virus type 1 clades on glial JC virus early and late gene transcription.PMID 23152365Read ↗

SMAD proteins of oligodendroglial cells regulate transcription of JC virus early and late genes coordinately with the Tat protein of human immunodeficiency virus type 1Semantic proximity Read ↗

Trans-activation of the JC virus late promoter by the tat protein of type 1 human immunodeficiency virus in glial cells.Semantic proximity Read ↗

Coordinate effects of human immunodeficiency virus type 1 protein Tat and cellular protein Puralpha on DNA replication initiated at the JC virus origin.Semantic proximity Read ↗

Activation of the JC virus Tat-responsive transcriptional control element by association of the Tat protein of human immunodeficiency virus 1 with cellular protein PurαSemantic proximity Read ↗

Tat is a multifunctional viral protein that modulates cellular gene expression and functionsSemantic proximity Read ↗

HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.Semantic proximity Read ↗

Regulation of Human Immunodeficiency Virus Type 1 Gene Expression by Clade-Specific Tat ProteinsSemantic proximity Read ↗

Clade‐specific differences in neurotoxicity of human immunodeficiency virus‐1 B and C Tat of human neurons: significance of dicysteine C30C31 motifSemantic proximity Read ↗

Multiple Actions of the Human Immunodeficiency Virus Type-1 Tat Protein on Microglial Cell FunctionsSemantic proximity Read ↗

JC virus promoter/enhancers contain TATA box-associated Spi-B-binding sites that support early viral gene expression in primary astrocytesSemantic proximity Read ↗

Rearranged JC Virus Noncoding Control Regions Found in Progressive Multifocal Leukoencephalopathy Patient Samples Increase Virus Early Gene Expression and Replication RateSemantic proximity Read ↗

The human JC polyomavirus (JCPyV): virological background and clinical implications.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.