Article
Hiv-1 Tat can substantially enhance the capacity of NIK to induce IkappaB degradation.
Biochemical and biophysical research communications - 24 Aug 2001
Li X, Josef J, Marasco W A
Abstract excerpt
The human immunodeficiency virus type 1 (HIV-1) Tat is a virally encoded protein that dramatically up-regulates viral replication through interactions with the HIV-1 5' long terminal repeat (LTR) and cellular transcription factors. The HIV-1 LTR is divided into three major regions: modulatory, core and TAR. The modulatory region contains numerous cis-acting sequences for the binding of transcription factors...
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