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Article

The C terminus of HIV-1 Tat modulates the extent of CD178-mediated apoptosis of T cells.

The Journal of biological chemistry - 18 Nov 2005

Campbell Grant R, Watkins Jennifer D, Esquieu Didier, Pasquier Eddy, Loret Erwann P, Spector Stephen A

Abstract excerpt

HIV infection and the progression to AIDS are characterized by the depletion of CD4(+) T cells through apoptosis of the uninfected bystander cells and the direct killing of HIV-infected cells. This is mediated in part by the human immunodeficiency virus, type 1 Tat protein, which is secreted by v...

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Source

Identifiers

PMID: 16155003
DOI: 10.1074/jbc.M506630200

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16155003-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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