Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The C terminus of HIV-1 Tat modulates the extent of CD178-mediated apoptosis of T cells.

The Journal of biological chemistry - 18 Nov 2005

Campbell Grant R, Watkins Jennifer D, Esquieu Didier, Pasquier Eddy, Loret Erwann P, Spector Stephen A

Abstract excerpt

HIV infection and the progression to AIDS are characterized by the depletion of CD4(+) T cells through apoptosis of the uninfected bystander cells and the direct killing of HIV-infected cells. This is mediated in part by the human immunodeficiency virus, type 1 Tat protein, which is secreted by virally infected cells and taken up by uninfected cells and CD178 gene expression, which is critically involved in T...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to Cell Separation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fas Ligand Protein

Share to fas Receptor

Share to Gene Products, tat

Share to Jurkat Cells

Share to Leukocytes, Mononuclear

Share to Tumor Necrosis Factors

Source

Identifiers

PMID: 16155003
DOI: 10.1074/jbc.M506630200

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The C terminus of HIV-1 Tat modulates the extent of CD178-mediated apoptosis of T cells.PMID 16155003Read ↗

Human Immunodeficiency Virus Type 1 Tat Induces Apoptosis and Increases Sensitivity to Apoptotic Signals by Up-Regulating FLICE/Caspase-8Semantic proximity Read ↗

The HIV-1 vpr R77Q Mutant Induces Apoptosis, G2 Cell Cycle Arrest, and Lower Production of Pro-Inflammatory Cytokines in Human CD4+ T Cells.Semantic proximity Read ↗

The HIV-1 Vpr R77Q mutant alters host apoptotic gene regulation in CD4+ T cells.Semantic proximity Read ↗

HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim.Semantic proximity Read ↗

HIV-1 Tat protein concomitantly down-regulates apical caspase-10 and up-regulates c-FLIP in lymphoid T cells: a potential molecular mechanism to escape TRAIL cytotoxicity.Semantic proximity Read ↗

PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins.Semantic proximity Read ↗

HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?Semantic proximity Read ↗

Increased mitochondrial mass characterizes the survival defect of HIV-specific CD8+ T cellsSemantic proximity Read ↗

HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells.Semantic proximity Read ↗

Human immunodeficiency virus type-1 protein Tat induces tumor necrosis factor-alpha-mediated neurotoxicity.Semantic proximity Read ↗

Clade‐specific differences in neurotoxicity of human immunodeficiency virus‐1 B and C Tat of human neurons: significance of dicysteine C30C31 motifSemantic proximity Read ↗

Inhibition of HIV‐1 Tat‐mediated LTR transactivation and HIV‐1 infection by anti‐Tat single chain intrabodies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.