Article
No association between a polymorphism in the steroid metabolism gene CYP17 and risk of breast cancer.
British journal of cancer - 1 Jun 1998
Dunning A M, Healey C S, Pharoah P D, Foster N A, Lipscombe J M, Redman K L, Easton D F, Day N E, Ponder B A
Abstract excerpt
A recent study showed an association between a single base substitution, T-->C, in the promotor region of the CYP17 gene, the risk of breast cancer and age at menarche in Asian, African-American and Latino women from California and Hawaii. The C allele was associated with increased risk of breast cancer, significantly so for patients presenting with advanced disease, whereas the TT genotype was associated with...
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