The CYP17A1 -34T > C polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers.

doi:10.1007/s10549-010-1123-5

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Article

The CYP17A1 -34T > C polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers.

Breast cancer research and treatment - 1 Apr 2011

Kaufman Bella, Laitman Yael, Ziv Elad, Hamann Ute, Torres Diana, Lahad Ephrat Levy, Beeri Rachel, Renbaum Paul, Jakubowska Anna, Lubinski Jan, Huzarski Tomasz, Tołoczko-Grabarek Aleksandra, Jaworska Katarzyna, Durda Katarzyna, Sprudle Amanda B, Chenevix-Trench Georgia, Simard Jacques, Easton Douglas F, Antonis Antoniou, Szabo Csilla, Friedman Eitan

Abstract excerpt

Exposure to estrogen has a major effect on breast cancer risk. A polymorphism (-34 T > C; rs743572) in the cytochrome P450c17alpha gene (CYP17A1) encoding an enzyme which controls estrogen levels was reportedly associated with breast cancer risk in average risk populations. The effect of this polymorphism on breast or ovarian cancer risk for BRCA1 and BRCA2 mutation carriers has not been thoroughly investigated....

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PMID: 20798986
DOI: 10.1007/s10549-010-1123-5

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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