Article
A search for type 1 diabetes susceptibility genes in families from the United Kingdom.
Nature genetics - 1 Jul 1998
Mein C A, Esposito L, Dunn M G, Johnson G C, Timms A E, Goy J V, Smith A N, Sebag-Montefiore L, Merriman M E, Wilson A J, Pritchard L E, Cucca F, Barnett A H, Bain S C, Todd J A
Abstract excerpt
Genetic analysis of a mouse model of major histocompatability complex (MHC)-associated autoimmune type 1 (insulin-dependent) diabetes mellitus (IDDM) has shown that the disease is caused by a combination of a major effect at the MHC and at least ten other susceptibility loci elsewhere in the genome. A genome-wide scan of 93 affected sibpair families (ASP) from the UK (UK93) indicated a similar genetic basis for...
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