Article
The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis.
Molecular cell - 1 Apr 1998
Yoshida K, Kondoh G, Matsuda Y, Habu T, Nishimune Y, Morita T
Abstract excerpt
The mouse Dmc1 gene is an E. coli RecA homolog that is specifically expressed in meiosis. The DMC1 protein was detected in leptotene-to-zygotene spermatocytes, when homolog pairing likely initiates. Targeted gene disruption in the male mouse showed an arrest of meiosis of germ cells at the early...
Topics
- Adenosine Triphosphatases
- Animals
- Blotting, Northern
- Cell Cycle Proteins
- Chromosomes
- DNA-Binding Proteins
- Female
- Gene Expression Regulation, Developmental
- Genotype
- Male
- Meiosis
- Mice
- Mice, Knockout
- Nuclear Proteins
- Ovary
- Phenotype
- Phosphate-Binding Proteins
- RNA, Messenger