Article
High copy number suppression of the meiotic arrest caused by a dmc1 mutation: REC114 imposes an early recombination block and RAD54 promotes a DMC1-independent DSB repair pathway.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Aug 1999
Bishop D K, Nikolski Y, Oshiro J, Chon J, Shinohara M, Chen X
Abstract excerpt
BACKGROUND: DMC1, the meiosis-specific eukaryotic homologue of bacterial recA, is required for completion of meiotic recombination and cell cycle progression past prophase. In a dmc1 mutant, double strand break recombination intermediates accumulate and cells arrest in prophase. We isolated genes which, when present at high copy numbers, suppress the meiotic arrest phenotype conferred by dmc1 mutations. RESULTS:...
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