Article
Association studies of polymorphisms of CYP2E1 gene in alcoholics with cirrhosis, antisocial personality, and normal controls.
Alcoholism, clinical and experimental research - 1 Jun 1998
Parsian A, Cloninger C R, Zhang Z H
Abstract excerpt
To determine the role of CYP2E1 gene in susceptibility to alcoholism and alcohol cirrhosis, we gentoyped a sample of alcoholics with and without cirrhosis, alcoholics with antisocial personality, alcoholic families, and normal controls with RsaI, PstI, and DraI polymorphisms in the gene. Relative...
Topics
- Adult
- Alcoholism
- Alleles
- Antisocial Personality Disorder
- Cytochrome P-450 CYP2E1
- Disease Susceptibility
- Female
- Gene Expression Regulation, Enzymologic
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Humans
- Linkage Disequilibrium
- Liver Cirrhosis, Alcoholic
- Male
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length