Variation in mutation rate and direction between tetranucleotide STR loci in human colorectal carcinomas.

doi:10.1046/j.1469-1809.1998.6210001.x

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Article

Variation in mutation rate and direction between tetranucleotide STR loci in human colorectal carcinomas.

Annals of human genetics - 1 Jan 1998

Hoff-Olsen P, Meling G I, Olaisen B

Abstract excerpt

Replication error (RER) is defined as mutation events in repetitive DNA segments. To investigate further the RER phenomenon and reveal any differences in mutation outcome between different short tandem repeat (STR) loci, we have investigated the somatic mutation rate and the size distribution of...

Topics

Adenocarcinoma
Alleles
Base Composition
Colorectal Neoplasms
Humans
Microsatellite Repeats
Mutation

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