Article
Variation in mutation rate and direction between tetranucleotide STR loci in human colorectal carcinomas.
Annals of human genetics - 1 Jan 1998
Hoff-Olsen P, Meling G I, Olaisen B
Abstract excerpt
Replication error (RER) is defined as mutation events in repetitive DNA segments. To investigate further the RER phenomenon and reveal any differences in mutation outcome between different short tandem repeat (STR) loci, we have investigated the somatic mutation rate and the size distribution of new tumour alleles in four tetranucleotide STRs in a large material of unselected colorectal adenocarcinomas. DNA was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.