Somatic mutations in VNTR-locus D1S7 in human colorectal carcinomas are associated with microsatellite instability.

doi:10.1002/humu.1380050410

Back to search

Article

Somatic mutations in VNTR-locus D1S7 in human colorectal carcinomas are associated with microsatellite instability.

Human mutation - 1 Jan 1995

Hoff-Olsen P, Meling G I, Olaisen B

Abstract excerpt

To elucidate mutation mechanisms in hypervariable VNTR loci, we have studied somatic mutation events with the minisatellite probe MS1 (VNTR locus D1S7) in 224 colorectal carcinomas (CRC). The D1S7 locus consists of a 9-basepair (bp) repeat unit. The copy number varies from about 100 to 2000, and...

Topics

Adenocarcinoma
Colorectal Neoplasms
DNA Mutational Analysis
DNA, Satellite
Genetic Markers
Humans
Minisatellite Repeats
Mutation
Polymerase Chain Reaction

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.