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Article

Somatic mutations in VNTR-locus D1S7 in human colorectal carcinomas are associated with microsatellite instability.

Human mutation - 1 Jan 1995

Hoff-Olsen P, Meling G I, Olaisen B

Abstract excerpt

To elucidate mutation mechanisms in hypervariable VNTR loci, we have studied somatic mutation events with the minisatellite probe MS1 (VNTR locus D1S7) in 224 colorectal carcinomas (CRC). The D1S7 locus consists of a 9-basepair (bp) repeat unit. The copy number varies from about 100 to 2000, and the germline mutation rate is high. Here we demonstrate a high D1S7 somatic mutation rate in CRC (37/224), higher than...

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PMID: 7627188
DOI: 10.1002/humu.1380050410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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