Article
Dynamic mutation loci: allele distributions in different populations.
Annals of human genetics - 1 Sept 1996
Richards R I, Crawford J, Narahara K, Mangelsdorf M, Friend K, Staples A, Denton M, Easteal S, Hori T A, Kondo I, Jenkins T, Goldman A, Panich V, Ferakova E, Sutherland G R
Abstract excerpt
To assess the relative contributions of trans-acting factors (replication and repair functions) and cis-acting elements (repeat and flanking DNA composition) to the mechanism of trinucleotide repeat sequence mutation we have analysed the distribution of copy number polymorphisms at 12 loci associated with dynamic mutations in 15 populations of different ethnic origins. Genome wide instability of repeats in a...
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