Article
Mutations in the E-domain of RAR portion of the PML/RAR chimeric gene may confer clinical resistance to all-trans retinoic acid in acute promyelocytic leukemia.
Blood - 15 Jul 1998
Imaizumi M, Suzuki H, Yoshinari M, Sato A, Saito T, Sugawara A, Tsuchiya S, Hatae Y, Fujimoto T, Kakizuka A, Konno T, Iinuma K
Abstract excerpt
The binding of all-trans retinoic acid (ATRA) to the ligand-binding region in the E-domain of retinoic acid receptor-alpha modifies the transcriptional activity of RARalpha protein. ATRA probably induces differentiation of acute promyelocytic leukemia (APL) cells by binding to the E-domain of the...
Topics
- Adolescent
- Adult
- Amino Acid Sequence
- Antineoplastic Agents
- Child
- Child, Preschool
- Drug Resistance, Neoplasm
- Female
- Humans
- Leukemia, Promyelocytic, Acute
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation