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Article

A mutated PML/RARA found in the retinoid maturation resistant NB4 subclone, NB4-R2, blocks RARA and wild-type PML/RARA transcriptional activities.

Leukemia - 1 Feb 2000

Duprez E, Benoit G, Flexor M, Lillehaug J R, Lanotte M

Abstract excerpt

The fusion protein PML/RARA, associated with acute promyelocytic leukemia behaves as an abnormal retinoic acid (RA) receptor with altered transactivation properties but is still inducible by RA. The chimeric protein is thought to promote leukemogenesis but also paradoxically to mediate the sensitivity to ATRA of APL cells. This has been supported by works reporting that in vitro ATRA resistance is characterized...

Read the complete abstract on PubMed

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Share to Leukemia, Promyelocytic, Acute
Share to Luciferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Confocal

Share to Oncogene Proteins, Fusion

Share to Receptors, Retinoic Acid

Share to Retinoic Acid Receptor alpha

Share to Sequence Analysis, RNA

Share to Tretinoin

Source

Identifiers

PMID: 10673742
DOI: 10.1038/sj.leu.2401683

Genes

RARA
PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A mutated PML/RARA found in the retinoid maturation resistant NB4 subclone, NB4-R2, blocks RARA and wild-type PML/RARA transcriptional activities.PMID 10673742Read ↗

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