Article
Novel mutation in the PML/RARalpha chimeric gene exhibits dramatically decreased ligand-binding activity and confers acquired resistance to retinoic acid in acute promyelocytic leukemia.
Experimental hematology - 1 Jul 2001
Takayama N, Kizaki M, Hida T, Kinjo K, Ikeda Y
Abstract excerpt
OBJECTIVE: All-trans retinoic acid (RA) resistance in acute promyelocytic leukemia (APL) has been a serious clinical problem in differentiation-inducing therapy. However, the mechanisms underlying acquired RA resistance in APL patients are not well understood. MATERIALS AND METHODS: We recently established a spontaneous RA-resistant APL cell line (UF-1) from a patient and used this cell line as an excellent in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.