Article
Mutations affecting both the rearranged and the unrearranged PML alleles in refractory acute promyelocytic leukaemia.
British journal of haematology - 1 Mar 2016
Iaccarino Licia, Ottone Tiziana, Divona Mariadomenica, Cicconi Laura, Cairoli Roberto, Voso Maria Teresa, Lo-Coco Francesco
Abstract excerpt
Acute promyelocytic leukaemia (APL) is characterized by the PML/RARA fusion transcript. PML and RARA mutations have been shown to directly respond to arsenic trioxide (ATO) and all-trans retinoic (ATRA). We analysed the prevalence of PML mutations in 32 patients with de novo or therapy-related APL (t-APL; n = 5), treated with ATO. We identified one ATO-resistant t-APL patient, who presented a PML A216T mutation...
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