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Article

Deregulated expression of TCL1 causes T cell leukemia in mice

31 Mar 1998

Abstract excerpt

The TCL1 oncogene on human chromosome 14q32.1 is involved in the development of T cell leukemia in humans. These leukemias are classified either as T prolymphocytic leukemias, which occur very late in life, or as T chronic lymphocytic leukemias, which often arise in patients with ataxia telangiectasia (AT) at a young age. The TCL1 oncogene is activated in these leukemias by juxtaposition to the alpha or beta...

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PMID: 9520462
DOI: 10.1073/pnas.95.7.3885

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