Article
Regulation of the glucocorticoid receptor gene by the AP-1 transcription factor.
Endocrine - 1 Dec 1997
Wei P, Vedeckis W V
Abstract excerpt
The glucocorticoid receptor (GR) is a ligand-activated nuclear transcription factor, and AP- 1 (Fos/Jun or Jun/Jun) is a transcription factor whose components are nuclear proteins encoded by c-fos and c-jun protooncogenes. Serum stimulation of serum-starved NIH 3T3 cells resulted in an approx 188-fold induction of c-fos mRNA at 30 min and an approximately ninefold induction of c-jun mRNA at 1 h, followed by an...
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