Article
Assessment of the role of activator protein-1 on transcription of the mouse steroidogenic acute regulatory protein gene.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 2004
Manna Pulak R, Eubank Darrell W, Stocco Douglas M
Abstract excerpt
cAMP-dependent mechanisms regulate the steroidogenic acute regulatory (StAR) protein even though its promoter lacks a consensus cAMP response-element (CRE, TGACGTCA). Transcriptional regulation of the StAR gene has been demonstrated to involve combinations of DNA sequences that provide recognition motifs for sequence-specific transcription factors. We recently identified and characterized three canonical 5'-CRE...
Topics
- Animals
- Binding Sites
- CCAAT-Enhancer-Binding Protein-beta
- Cells, Cultured
- Cyclic AMP
- DNA-Binding Proteins
- GATA4 Transcription Factor
- Gene Expression Regulation
- Humans
- Leydig Cells
- Male