A subset of notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex.

doi:10.1242/dev.125.15.2893

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Article

A subset of notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex.

Development (Cambridge, England) - 1 Aug 1998

Ligoxygakis P, Yu S Y, Delidakis C, Baker N E

Abstract excerpt

The Notch signalling pathway is involved in many processes where cell fate is decided. Previous work showed that Notch is required at successive steps during R8 specification in the Drosophila eye. Initially, Notch enhances atonal expression and promotes atonal function. After atonal autoregulati...

Topics

Animals
Basic Helix-Loop-Helix Transcription Factors
Body Patterning
Calcium-Binding Proteins
Cell Differentiation
Clone Cells
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Eye
Genes, Insect
Helix-Loop-Helix Motifs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insect Proteins

Intercellular Signaling Peptides and Proteins

Intracellular Signaling Peptides and Proteins

Jagged-1 Protein

Ligands

Membrane Proteins

Source

Open in PubMed

Identifiers

PMID: 9655811
DOI: 10.1242/dev.125.15.2893

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9655811-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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A subset of notch functions during Drosophila eye development require Su(H) and the E(spl) gene complex.PMID 9655811Read ↗

Notchspl is deficient for inductive processes in the eye, and E(spl)D enhances split by interfering with proneural activity.Semantic proximity Read ↗

Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development.Semantic proximity Read ↗

The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.Semantic proximity Read ↗

Analysis of transient hypermorphic activity of E(spl)D during R8 specification.Semantic proximity Read ↗

Evolution of proneural atonal expression during distinct regulatory phases in the developing Drosophila eye.Semantic proximity Read ↗

Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate.Semantic proximity Read ↗

Enhancer of split [E(spl)(D)] is a gro-independent, hypermorphic mutation in Drosophila.Semantic proximity Read ↗

Persistent expression of genes of the enhancer of split complex suppresses neural development in Drosophila.Semantic proximity Read ↗

Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila.Semantic proximity Read ↗

A Notch-independent function of Suppressor of Hairless during the development of the bristle sensory organ precursor cell of Drosophila.Semantic proximity Read ↗

Neurogenic phenotypes induced by RNA interference with bHLH genes of the Enhancer of split complex of Drosophila melanogaster.Semantic proximity Read ↗

Notch and Wingless modulate the response of cells to Hedgehog signalling in the Drosophila wing.Semantic proximity Read ↗

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