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Article

Enhancer of split [E(spl)(D)] is a gro-independent, hypermorphic mutation in Drosophila.

Developmental genetics - 1 Jan 1999

Nagel A C, Yu Y, Preiss A

Abstract excerpt

Enhancer of split [E(spl)] refers to a gene complex in Drosophila melanogaster, which contains a number of target genes of the Notch signaling pathway. The complex was originally identified by a dominant mutation E(spl)(D) that displays allele-specific interactions with a recessive mutation in the Notch locus called split (N(spl)). The spl phenotype is characterized by smaller eyes with irregularly spaced...

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Identifiers

PMID: 10440851
DOI: 10.1002/(SICI)1520-6408(1999)25:2<168::AID-DVG11>3.0.CO;2-0

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Enhancer of split [E(spl)(D)] is a gro-independent, hypermorphic mutation in Drosophila.PMID 10440851Read ↗

Enhancer of splitD, a dominant mutation of Drosophila, and its use in the study of functional domains of a helix-loop-helix protein.Semantic proximity Read ↗

Functional dissection of the Drosophila enhancer of split protein, a suppressor of neurogenesis.Semantic proximity Read ↗

Notchspl is deficient for inductive processes in the eye, and E(spl)D enhances split by interfering with proneural activity.Semantic proximity Read ↗

Deletion mapping in the Enhancer of split complex.Semantic proximity Read ↗

Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster.Semantic proximity Read ↗

The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.Semantic proximity Read ↗

Neurogenic phenotypes induced by RNA interference with bHLH genes of the Enhancer of split complex of Drosophila melanogaster.Semantic proximity Read ↗

Persistent expression of genes of the enhancer of split complex suppresses neural development in Drosophila.Semantic proximity Read ↗

A chimeric enhancer-of-split transcriptional activator drives neural development and achaete-scute expression.Semantic proximity Read ↗

The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts.Semantic proximity Read ↗

The Enhancer of split complex and adjacent genes in the 96F region of Drosophila melanogaster are required for segregation of neural and epidermal progenitor cells.Semantic proximity Read ↗

Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators.Semantic proximity Read ↗

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