Article
Notchspl is deficient for inductive processes in the eye, and E(spl)D enhances split by interfering with proneural activity.
Developmental biology - 15 Apr 1999
Nagel A C, Preiss A
Abstract excerpt
Eye development in Drosophila involves the Notch signaling pathway at several consecutive steps. At first, Notch signaling is required for stable expression of the proneural gene atonal (ato), thereby maintaining neural potential of the cells. Second, in a process of lateral inhibition, Notch signaling is necessary to confine neural commitment to individual photoreceptor founder cells. Later on, the successive...
Topics
- Alleles
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Body Patterning
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Embryonic Induction
- Eye
- Gene Dosage
- Helix-Loop-Helix Motifs
- Insect Proteins
- Membrane Proteins
- Models, Biological
- Mutation
- Protein Binding
- Receptors, Notch
- Repressor Proteins