Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired cerebellar long-term potentiation in type I adenylyl cyclase mutant mice.

Neuron - 1 Jun 1998

Storm D R, Hansel C, Hacker B, Parent A, Linden D J

Abstract excerpt

Activation of adenylyl cyclase and the consequent production of cAMP is a process that has been shown to be central to invertebrate model systems of information storage. In the vertebrate brain, it has been suggested that a presynaptic cascade involving Ca influx, cAMP production, and subsequent activation of cAMP-dependent protein kinase is necessary for induction of long-term potentiation (LTP) at the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to Cell Membrane
Share to Cyclic AMP

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Inhibitors

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Share to Mutation

Source

Identifiers

PMID: 9655507
DOI: 10.1016/s0896-6273(00)80500-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired cerebellar long-term potentiation in type I adenylyl cyclase mutant mice.PMID 9655507Read ↗

alphaCaMKII Is essential for cerebellar LTD and motor learning.Semantic proximity Read ↗

Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I.Semantic proximity Read ↗

Genetic and pharmacological demonstration of a role for cyclic AMP-dependent protein kinase-mediated suppression of protein phosphatases in gating the expression of late LTP.Semantic proximity Read ↗

Suppression of inhibitory GABAergic transmission by cAMP signaling pathway: alterations in learning and memory mutants.Semantic proximity Read ↗

A genetic test of the effects of mutations in PKA on mossy fiber LTP and its relation to spatial and contextual learning.Semantic proximity Read ↗

Deficient long-term synaptic depression in the rostral cerebellum correlated with impaired motor learning in phospholipase C beta4 mutant mice.Semantic proximity Read ↗

Long-term potentiation and adenosine sensitivity are unchanged in the AS/AGU protein kinase Cgamma-deficient rat.Semantic proximity Read ↗

The regulatory diversity of the mammalian adenylyl cyclases.Semantic proximity Read ↗

Global and local missions of cAMP signaling in neural plasticity, learning, and memorySemantic proximity Read ↗

Acute in vivo genetic rescue demonstrates that phosphorylation of RIM1alpha serine 413 is not required for mossy fiber long-term potentiation.Semantic proximity Read ↗

Reassessment of long-term depression in cerebellar Purkinje cells in mice carrying mutated GluA2 C terminus.Semantic proximity Read ↗

RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.