Article
Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma.
Nature medicine - 1 Nov 2008
Pule Martin A, Savoldo Barbara, Myers G Doug, Rossig Claudia, Russell Heidi V, Dotti Gianpietro, Huls M Helen, Liu Enli, Gee Adrian P, Mei Zhuyong, Yvon Eric, Weiss Heidi L, Liu Hao, Rooney Cliona M, Heslop Helen E, Brenner Malcolm K
Abstract excerpt
Cytotoxic T lymphocytes (CTLs) directed to nonviral tumor-associated antigens do not survive long term and have limited antitumor activity in vivo, in part because such tumor cells typically lack the appropriate costimulatory molecules. We therefore engineered Epstein-Barr virus (EBV)-specific CTLs to express a chimeric antigen receptor directed to the diasialoganglioside GD2, a nonviral tumor-associated antigen...
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