Article
Bax-mediated cell death by the Gax homeoprotein requires mitogen activation but is independent of cell cycle activity.
The EMBO journal - 1 Jul 1998
Perlman H, Sata M, Le Roux A, Sedlak T W, Branellec D, Walsh K
Abstract excerpt
Tissues with the highest rates of proliferation typically exhibit the highest frequencies of apoptosis, but the mechanisms that coordinate these processes are largely unknown. The homeodomain protein Gax is down-regulated when quiescent cells are stimulated to proliferate, and constitutive Gax ex...
Topics
- Animals
- Apoptosis
- Cell Cycle
- Cells, Cultured
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- G1 Phase
- Homeodomain Proteins
- Hydroxyurea
- Male
- Mice
- Mitogens
- Muscle Proteins