Article
Suppression of apoptosis by basement membrane requires three-dimensional tissue organization and withdrawal from the cell cycle.
Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 1996
Boudreau N, Werb Z, Bissell M J
Abstract excerpt
The basement membrane (BM) extracellular matrix induces differentiation and suppresses apoptosis in mammary epithelial cells, whereas cells lacking BM lose their differentiated phenotype and undergo apoptosis. Addition of purified BM components, which are known to induce beta-casein expression, d...
Topics
- Animals
- Apoptosis
- Basement Membrane
- Caspase 1
- Cell Cycle
- Cell Differentiation
- Cell Line
- Cysteine Endopeptidases
- Epithelial Cells
- Epithelium
- Extracellular Matrix
- Female
- Genes, myc
- Homeostasis
- Mammary Glands, Animal
- Mice
- Phenotype
- RNA, Messenger