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Article

bcl-2 overexpression promotes myocyte proliferation.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2002

Limana Federica, Urbanek Konrad, Chimenti Stefano, Quaini Federico, Leri Annarosa, Kajstura Jan, Nadal-Ginard Bernardo, Izumo Seigo, Anversa Piero

Abstract excerpt

To determine the influence of Bcl-2 on the developmental biology of myocytes, we analyzed the population dynamics of this cell type in the heart of transgenic (TG) mice overexpressing Bcl-2 under the control of the alpha-myosin heavy chain promoter. TG mice and non-TG (wild type, WT) mice were studied at 24 days, 2 months, and 4 months after birth. Bcl-2 overexpression produced a significant increase in the...

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Identifiers

PMID: 11983915
DOI: 10.1073/pnas.092672899
PMCID: PMC122936

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Source receipt: pubmed, retrieved 7 Sept 2026.

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