Involvement of the rolled/MAP kinase gene in Drosophila mitosis: interaction between genes for the MAP kinase cascade and abnormal spindle.

doi:10.1007/s004380050739

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Article

Involvement of the rolled/MAP kinase gene in Drosophila mitosis: interaction between genes for the MAP kinase cascade and abnormal spindle.

Molecular & general genetics : MGG - 1 May 1998

Inoue Y H, Glover D M

Abstract excerpt

We have found that mutations that lead to loss of rolled/MAP kinase function result in a reduced mitotic index in the larval central nervous system, consistent with an interphase block to cell cycle progression, associated with a low frequency of cells showing chromosome over-condensation in mito...

Topics

Animals
Calcium-Calmodulin-Dependent Protein Kinases
Drosophila
Drosophila Proteins
Enzyme Activation
Extracellular Signal-Regulated MAP Kinases
Female
Fertility
Genes, Insect
Male
Microfilament Proteins
Microtubule-Associated Proteins
Microtubules
Mitosis
Mutation
Phenotype

Source

Open in PubMed

Identifiers

PMID: 9648737
DOI: 10.1007/s004380050739

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9648737-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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