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Article

Longitudinal SPECT study in Alzheimer's disease: relation to apolipoprotein E polymorphism.

Journal of neurology, neurosurgery, and psychiatry - 1 Jun 1998

Lehtovirta M, Kuikka J, Helisalmi S, Hartikainen P, Mannermaa A, Ryynänen M, Riekkinen PSr, Soininen H

Abstract excerpt

OBJECTIVES: In mild Alzheimer's disease, SPECT imaging of regional cerebral blood flow has highlighted deficits in the posterior association cortex, and later in the disease process, the deficit spreads to involve the frontal cortex. The sigma4 allele of apolipoprotein E is a risk factor for Alzheimer's disease. The effect of apolipoprotein E polymorphism on cerebral perfusion was studied. The hypothesis was that...

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Identifiers

PMID: 9647302
DOI: 10.1136/jnnp.64.6.742
PMCID: PMC2170126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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