Longitudinal SPECT study in Alzheimer's disease: relation to apolipoprotein E polymorphism.

doi:10.1136/jnnp.64.6.742

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Article

Longitudinal SPECT study in Alzheimer's disease: relation to apolipoprotein E polymorphism.

Journal of neurology, neurosurgery, and psychiatry - 1 Jun 1998

Lehtovirta M, Kuikka J, Helisalmi S, Hartikainen P, Mannermaa A, Ryynänen M, Riekkinen PSr, Soininen H

Abstract excerpt

OBJECTIVES: In mild Alzheimer's disease, SPECT imaging of regional cerebral blood flow has highlighted deficits in the posterior association cortex, and later in the disease process, the deficit spreads to involve the frontal cortex. The sigma4 allele of apolipoprotein E is a risk factor for Alzh...

Topics

Aged
Alleles
Alzheimer Disease
Apolipoproteins E
Brain
Female
Follow-Up Studies
Genotype
Humans
Longitudinal Studies
Male
Polymerase Chain Reaction
Polymorphism, Genetic
Radiopharmaceuticals
Regional Blood Flow

Source

Open in PubMed Open full text

Identifiers

PMID: 9647302
DOI: 10.1136/jnnp.64.6.742
PMCID: PMC2170126

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9647302-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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