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Article

Apolipoprotein E genotype and early Alzheimer's disease: a longitudinal SPECT study.

Journal of neuroimaging : official journal of the American Society of Neuroimaging - 1 Apr 2003

Sakamoto Shigeki, Matsuda Hiroshi, Asada Takashi, Ohnishi Takashi, Nakano Seigo, Kanetaka Hidekazu, Takasaki Masaru

Abstract excerpt

BACKGROUND AND PURPOSE: To determine the association of the apolipoprotein E (APOE) genotype and longitudinal changes of regional cerebral blood flow (rCBF) in Alzheimer's disease (AD). Previous reports have yielded conflicting results concerning this association. METHODS: A retrospective cohort study was performed. rCBF was noninvasively measured using 99mTc-ethyl cysteinate dimer single-photon emission computed...

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Source

Identifiers

PMID: 12722493

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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