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Article

Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-Tyr705 largely through TC45.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Feb 2012

Wakahara Ryohei, Kunimoto Hiroyuki, Tanino Kanae, Kojima Hirotada, Inoue Akira, Shintaku Haruo, Nakajima Koichi

Abstract excerpt

Signal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic transcription factor. It is activated by cytokines, including interleukin-6 (IL-6) through phosphorylation at Tyr705 (pY705), which is required for its dimerization and nuclear translocation. However, the role of Ser727 phosphorylation, occurring during activation, remains poorly understood. Using a combination of...

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Source

Identifiers

PMID: 22233524
DOI: 10.1111/j.1365-2443.2011.01575.x

Genes

STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phospho-Ser727 of STAT3 regulates STAT3 activity by enhancing dephosphorylation of phospho-Tyr705 largely through TC45.PMID 22233524Read ↗

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