Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation.

Cellular signalling - 1 Dec 2005

Haan Serge, Keller Julia F, Behrmann Iris, Heinrich Peter C, Haan Claude

Abstract excerpt

IL-6-type cytokines play an important role during inflammation and the immune response. In addition, they are involved in haematopoiesis, liver and neuronal regeneration, embryonic development and fertility. We found that IL-6-type cytokine stimulation of cell lines and primary human macrophages results in a different distribution of the DNA-binding competent STAT dimer species in the cytosol and nucleus as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Cytosol
Share to Dimerization

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interferon-alpha

Share to Interferon-gamma

Share to Interleukin-6

Share to Janus Kinase 1

Share to STAT1 Transcription Factor

Source

Identifiers

PMID: 15935617
DOI: 10.1016/j.cellsig.2005.03.010

Genes

STAT1
STAT3
OSM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation.PMID 15935617Read ↗

Ups and downs: The STAT1:STAT3 seesaw of Interferon and gp130 receptor signallingSemantic proximity Read ↗

The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responsesSemantic proximity Read ↗

STAT2 and IRF9Semantic proximity Read ↗

STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling PathwaysSemantic proximity Read ↗

Human B lymphoblast cell lines defective of Stat6 signaling produce high levels of proinflammatory cytokines IL-12, TNFalpha and IFNgamma.Semantic proximity Read ↗

Interleukin-6 at the Host-Tumor Interface: STAT3 in Biomolecular Condensates in Cancer CellsSemantic proximity Read ↗

Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.Semantic proximity Read ↗

The STAT3 isoforms alpha and beta have unique and specific functions.Semantic proximity Read ↗

Interleukin 4 Regulates Phosphorylation of Serine 756 in the Transactivation Domain of Stat6Semantic proximity Read ↗

Dominant-negative activity of the STAT3-Y705F mutant depends on the N-terminal domain.Semantic proximity Read ↗

Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses in autoimmune disordersSemantic proximity Read ↗

Human Cytomegalovirus IE1 Protein Disrupts Interleukin-6 Signaling by Sequestering STAT3 in the NucleusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.