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Article

Role of LpL (Lipoprotein Lipase) in Macrophage Polarization In Vitro and In Vivo

22 Aug 2019

Abstract excerpt

Objective: Fatty acid uptake and oxidation characterize the metabolism of alternatively activated macrophage polarization in vitro, but the in vivo biology is less clear. We assessed the roles of LpL (lipoprotein lipase)-mediated lipid uptake in macrophage polarization in vitro and in several important tissues in vivo. Approach and Results: We created mice with both global and myeloid-cell specific LpL...

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PMID: 31434492
DOI: 10.1161/atvbaha.119.312389

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