Long-term postmortem survival of mitochondrial genomes in mouse synaptosomes and their rescue in a mitochondrial DNA-less mouse cell line.

doi:10.1006/bbrc.1998.8800

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Article

Long-term postmortem survival of mitochondrial genomes in mouse synaptosomes and their rescue in a mitochondrial DNA-less mouse cell line.

Biochemical and biophysical research communications - 18 Jun 1998

Ito S, Inoue K, Yanagisawa N, Kaneko M, Hayashi J

Abstract excerpt

Mitochondrial DNA (mtDNA) transfer was carried out from postmortem mouse tissues to mouse mtDNA-less (rho0) cells to determine how long it takes for autolysis of mtDNA after death and whether mtDNA in postmortem tissues can recover its function in rho0 cells. The results showed that mtDNA was sta...

Topics

Aging
Animals
Brain
Cell Line
DNA, Mitochondrial
Drug Stability
Genome
Humans
Kinetics
Mice
Mitochondria
Mitosis
Mutation
Synaptosomes

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