Article
Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiation.
Cell proliferation - 1 Aug 2009
Kirby D M, Rennie K J, Smulders-Srinivasan T K, Acin-Perez R, Whittington M, Enriquez J-A, Trevelyan A J, Turnbull D M, Lightowlers R N
Abstract excerpt
OBJECTIVES: Defects of the mitochondrial genome (mtDNA) cause a series of rare, mainly neurological disorders. In addition, they have been implicated in more common forms of movement disorders, dementia and the ageing process. In order to try to model neuronal dysfunction associated with mitochondrial disease, we have attempted to establish a series of transmitochondrial mouse embryonic stem cells harbouring...
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