Article
beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes.
Genes & development - 15 Jun 1998
Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H
Abstract excerpt
To study the late beta-cell-specific function of the homeodomain protein IPF1/PDX1 we have generated mice in which the Ipf1/Pdx1 gene has been disrupted specifically in beta cells. These mice develop diabetes with age, and we show that IPF1/PDX1 is required for maintaining the beta cell identity...
Topics
- Amyloid
- Animals
- Blood Glucose
- Cell Line
- Diabetes Mellitus, Type 2
- Gene Expression Regulation
- Genes
- Glucagon
- Glucose Intolerance
- Glucose Tolerance Test
- Glucose Transporter Type 2
- Heterozygote
- Homeodomain Proteins
- Immunohistochemistry
- Insulin
- Islet Amyloid Polypeptide
- Islets of Langerhans
- Mice