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Article

Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1.

Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 1996

Serup P, Jensen J, Andersen F G, Jørgensen M C, Blume N, Holst J J, Madsen O D

Abstract excerpt

Insulin promoter factor 1 (IPF1), a member of the homeodomain protein family, serves an early role in pancreas formation, as evidenced by the lack of pancreas formation in mice carrying a targeted disruption of the IPF1 gene [Jonsson, J., Carlsson, L., Edlund, T. & Edlund, H. (1994) Nature (Londo...

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Identifiers

PMID: 8799146
DOI: 10.1073/pnas.93.17.9015
PMCID: PMC38587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-8799146-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1.PMID 8799146Read ↗

Insulin-promoter-factor 1 is required for pancreas development in mice.Semantic proximity Read ↗

Transcription factors contributing to the pancreatic beta-cell phenotype.Semantic proximity Read ↗

Purification of the β-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cellsSemantic proximity Read ↗

Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1.Semantic proximity Read ↗

beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes.Semantic proximity Read ↗

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus.Semantic proximity Read ↗

IPF1, a homeodomain‐containing transactivator of the insulin gene.Semantic proximity Read ↗

Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes.Semantic proximity Read ↗

Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein.Semantic proximity Read ↗

Transforming growth factor beta induction of insulin gene expression is mediated by pancreatic and duodenal homeobox gene-1 in rat insulinoma cells.Semantic proximity Read ↗

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence.Semantic proximity Read ↗

Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene).Semantic proximity Read ↗

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