Article
Ly-49-independent natural killer (NK) cell specificity revealed by NK cell clones derived from p53-deficient mice.
The Journal of experimental medicine - 1 May 1995
Karlhofer F M, Orihuela M M, Yokoyama W M
Abstract excerpt
Natural killer (NK) cells are heterogeneous in their specificity and expression of cell surface molecules. In the mouse, the Ly-49A molecule is a primary determinant of NK cell specificity because of its ability to downregulate NK cell activation after physical interaction with target cell MHC cl...
Topics
- Animals
- Antigens, Ly
- Clone Cells
- Gene Rearrangement, T-Lymphocyte
- Histocompatibility Antigens Class I
- Killer Cells, Natural
- Lectins, C-Type
- Membrane Glycoproteins
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mutation
- Receptors, NK Cell Lectin-Like
- Sensitivity and Specificity
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53