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Article

Mechanisms of increased NGF production in vascular smooth muscle of the spontaneously hypertensive rat.

Experimental cell research - 25 May 1998

Sherer T B, Neff P S, Hankins G R, Tuttle J B

Abstract excerpt

The spontaneously hypertensive rat (SHR) was developed as a genetic model of essential hypertension. In vivo and in vitro evidence demonstrates that vascular smooth muscle cells (VSMCs) from the SHR produce more nerve growth factor (NGF) than the normotensive Wistar-Kyoto (WKY) control strain. This increased NGF production is accompanied by excessive innervation of target tissues in the SHR. In the present study,...

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Source

Identifiers

PMID: 9633527
DOI: 10.1006/excr.1998.4043

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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