Article
Spironolactone reduces cerebral infarct size and EGF-receptor mRNA in stroke-prone rats.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 Sept 2001
Dorrance A M, Osborn H L, Grekin R, Webb R C
Abstract excerpt
Remodeling of the cerebral vasculature contributes to the pathogenesis of cerebral ischemia. Remodeling is caused by increased smooth muscle proliferation and may be due to an increase in the responsiveness of vascular cells to epidermal growth factor (EGF). Aldosterone is a risk factor for stroke, and the literature suggests it may play a role in increasing the expression of the receptor for EGF (EGFR). We...
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