Article
Low affinity nerve growth factor receptor gene co-segregates with decreased bodyweight and increased left ventricular weight in spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology - 1 Jan 2000
Kapuscinski M K, Nemoto K, Ueyama T, Charchar F, Kageyama H, Fukumachi K, Sekimoto M, Senba E, Tomita T, Tomita I, Harrap S B
Abstract excerpt
1. The sympathetic nervous system influences the cardiovascular and hormonal systems and sympathetic innervation is dependent on nerve growth factor (NGF). The NGF gene is linked genetically to high blood pressure in the spontaneously hypertensive rat (SHR) and there exists a mutation in the SHR low affinity NGF receptor (LNGFR) gene. 2. To determine whether the LNGFR mutation was linked genetically with...
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