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Article

Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice.

Molecular and cellular biology - 1 Jul 1998

Xu Y, Yang E M, Brugarolas J, Jacks T, Baltimore D

Abstract excerpt

Disruption of the mouse Atm gene, whose human counterpart is consistently mutated in ataxia-telangiectasia (A-T) patients, creates an A-T mouse model exhibiting most of the A-T-related systematic and cellular defects. While ATM plays a major role in signaling the p53 response to DNA strand break damage, Atm-/- p53(-/-) mice develop lymphomas earlier than Atm-/- or p53(-/-) mice, indicating that mutations in these...

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Identifiers

PMID: 9632822
DOI: 10.1128/MCB.18.7.4385
PMCID: PMC109022

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice.PMID 9632822Read ↗

Loss of <i>p</i> 21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in <i>atm</i> -deficient miceSemantic proximity Read ↗

ATM: the product of the gene mutated in ataxia-telangiectasia.Semantic proximity Read ↗

Atm-deficient mice: a paradigm of ataxia telangiectasia.Semantic proximity Read ↗

ATM: the protein encoded by the gene mutated in the radiosensitive syndrome ataxia-telangiectasia.Semantic proximity Read ↗

ATM activity in T cells is critical for immune surveillance of lymphoma in vivo.Semantic proximity Read ↗

The cGAS–STING, p38 MAPK, and p53 pathways link genome instability to accelerated cellular senescence in ATM-deficient murine lung fibroblastsSemantic proximity Read ↗

Atm and c-Abl cooperate in the response to genotoxic stress during nervous system development.Semantic proximity Read ↗

Cancer risk and the ATM gene: a continuing debate.Semantic proximity Read ↗

Atm-haploinsufficiency enhances susceptibility to carcinogen-induced mammary tumors.Semantic proximity Read ↗

Absence of Wip1 partially rescues Atm deficiency phenotypes in mice.Semantic proximity Read ↗

Induction and Utilization of an ATM Signaling Pathway by PolyomavirusSemantic proximity Read ↗

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.Semantic proximity Read ↗

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