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Article

Astrocytic alterations in interleukin-6/Soluble interleukin-6 receptor alpha double-transgenic mice.

The American journal of pathology - 1 Nov 2000

Brunello A G, Weissenberger J, Kappeler A, Vallan C, Peters M, Rose-John S, Weis J

Abstract excerpt

Interleukin-6 (IL-6), a major cytokine with diverse effects on cells mainly of the immune and hematopoietic systems, has been linked to several neurological disorders such as acquired immune deficiency syndrome dementia, multiple sclerosis, and Alzheimer's disease. Central nervous system (CNS)-specific expression of IL-6 caused neurodegeneration, massive gliosis, and vascular proliferation in transgenic mice....

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Identifiers

PMID: 11073809
DOI: 10.1016/s0002-9440(10)64787-6
PMCID: PMC1885732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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