Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jan 2002

Vallières Luc, Campbell Iain L, Gage Fred H, Sawchenko Paul E

Abstract excerpt

Postnatal neurogenesis can be modulated after brain injury, but the role of the attendant expression of inflammatory mediators in such responses remains to be determined. Here we report that transgenically directed production of interleukin-6 (IL-6) by astroglia decreased overall neurogenesis by 63% in the hippocampal dentate gyrus of young adult transgenic mice. The proliferation, survival, and differentiation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Bromodeoxyuridine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Count

Share to Dentate Gyrus

Share to Fluoresceins

Share to Fluorescent Dyes

Share to Hippocampus

Share to Organic Chemicals

Source

Open in PubMed Open full text

Identifiers

PMID: 11784794
PMCID: PMC6758670

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6.PMID 11784794Read ↗

Structural and Functional Impact of the Transgenic Expression of Cytokines in the CNSaSemantic proximity Read ↗

Astrocytic alterations in interleukin-6/Soluble interleukin-6 receptor alpha double-transgenic mice.Semantic proximity Read ↗

Chronic exposure to IL-6 induces a desensitized phenotype of the microglia.Semantic proximity Read ↗

Transgenic techniques for cell ablation or molecular deletion to investigate functions of astrocytes and other GFAP-expressing cell types.Semantic proximity Read ↗

Increased post-traumatic survival of neurons in IL-6-knockout mice on a background of EAE susceptibility.Semantic proximity Read ↗

Reduced hippocampal neurogenesis in R6/2 transgenic Huntington's disease miceSemantic proximity Read ↗

Microglia regulate adult neurogenesis via interleukin-6 trans-signaling triggered by apoptotic progenitorsSemantic proximity Read ↗

Conditional ablation of cerebellar astrocytes in postnatal transgenic mice.Semantic proximity Read ↗

SRF-deficient astrocytes provide neuroprotection in mouse models of excitotoxicity and neurodegenerationSemantic proximity Read ↗

Chronic Overproduction of Transforming Growth Factor-β1 by Astrocytes Promotes Alzheimer's Disease-Like Microvascular Degeneration in Transgenic MiceSemantic proximity Read ↗

Glial-Restricted Precursors stimulate endogenous cytogenesis and effectively recover emotional deficits in a model of cytogenesis ablationSemantic proximity Read ↗

Mild traumatic brain injury induces transient, sequential increases in proliferation, neuroblasts/immature neurons, and cell survival: a time course study in the male mouse dentate gyrusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.