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Article

Potassium channel openers require ATP to bind to and act through sulfonylurea receptors.

The EMBO journal - 1 Oct 1998

Schwanstecher M, Sieverding C, Dörschner H, Gross I, Aguilar-Bryan L, Schwanstecher C, Bryan J

Abstract excerpt

KATP channels are composed of a small inwardly rectifying K+ channel subunit, either KIR6.1 or KIR6.2, plus a sulfonylurea receptor, SUR1 or SUR2 (A or B), which belong to the ATP-binding cassette superfamily. SUR1/KIR6.2 reconstitute the neuronal/pancreatic beta-cell channel, whereas SUR2A/KIR6.2 and SUR2B/KIR6.1 (or KIR6.2) are proposed to reconstitute the cardiac and the vascular-smooth-muscle-type KATP...

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Identifiers

PMID: 9755153
DOI: 10.1093/emboj/17.19.5529
PMCID: PMC1170881

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Related research

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Potassium channel openers require ATP to bind to and act through sulfonylurea receptors.PMID 9755153Read ↗

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ATP-sensitive potassium channels: a model of heteromultimeric potassium channel/receptor assemblies.Semantic proximity Read ↗

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The Pharmacology of ATP-Sensitive K+ Channels (KATP).Semantic proximity Read ↗

Molecular determinants of KATP channel inhibition by ATP.Semantic proximity Read ↗

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