Article
Potassium channel openers require ATP to bind to and act through sulfonylurea receptors.
The EMBO journal - 1 Oct 1998
Schwanstecher M, Sieverding C, Dörschner H, Gross I, Aguilar-Bryan L, Schwanstecher C, Bryan J
Abstract excerpt
KATP channels are composed of a small inwardly rectifying K+ channel subunit, either KIR6.1 or KIR6.2, plus a sulfonylurea receptor, SUR1 or SUR2 (A or B), which belong to the ATP-binding cassette superfamily. SUR1/KIR6.2 reconstitute the neuronal/pancreatic beta-cell channel, whereas SUR2A/KIR6....
Topics
- ATP-Binding Cassette Transporters
- Adenosine Triphosphate
- Animals
- Binding Sites
- Binding, Competitive
- Cricetinae
- Diazoxide
- Glyburide
- Guanidines
- Humans
- Mutation
- Peptide Fragments
- Pinacidil
- Potassium Channels
- Potassium Channels, Inwardly Rectifying
- Protein Isoforms
- Pyridines
- Receptors, Drug