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Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir‐binding site

1 Apr 2004

Abstract excerpt

The crystal structures of the wild-type HIV-1 protease (PR) and the two resistant variants, PR(V82A) and PR(L90M), have been determined in complex with the antiviral drug, indinavir, to gain insight into the molecular basis of drug resistance. V82A and L90M correspond to an active site mutation and nonactive site mutation, respectively. The inhibition (K(i)) of PR(V82A) and PR(L90M) was 3.3- and 0.16-fold,...

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PMID: 15066177
DOI: 10.1111/j.1432-1033.2004.04060.x

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