Article
Gene trap expression and mutational analysis for genes involved in the development of the mammalian nervous system.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 1998
Stoykova A, Chowdhury K, Bonaldo P, Torres M, Gruss P
Abstract excerpt
We have used a large-scale gene trap approach for the isolation and mutation of genes that might play roles in the developing nervous system. After in vitro integration of two different gene trap vectors (pGT1.8geo: Skarnes et al. [1995] Proc. Natl. Acad. Sci. USA 92:6592-6596; IRES beta geo: Chowdhury et al. [1997] Nucleic Acids Res. 25:1531-1536) in mouse embryonic stem (ES) cell lines, we created 64 transgenic...
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