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Article

A methylenetetrahydrofolate reductase polymorphism is associated with expression of p16 in human lung cancer.

Oncology reports - 1 Jan 2000

Kamiya H, Kawakami K, Miyanaga T, Omura K, Oda M, Murakami S, Watanabe Y

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in the folate cycle. Reduced MTHFR activity induces DNA hypomethylation and stability, which may protect the tumor suppressor gene p16INK4. We examined the association between MTHFR polymorphism and expression of p16INK4. The frequency of the MTHFR genotypes were 21 Ala/Ala, 29 Ala/Aal, and 7 Val/Val. Expression of p16INK4 was 26.2 +/- 26.8% in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Gene Expression Regulation, Neoplastic

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Share to Lung Neoplasms

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 9625844
DOI: 10.3892/or.5.4.911

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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