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Article

Methylenetetrahydrofolate reductase polymorphism is associated with folate pool in gastrointestinal cancer tissue.

Anticancer research - 1 Jan 2000

Kawakami K, Omura K, Kanehira E, Watanabe G

Abstract excerpt

The folate pool in cancer tissue is a critical factor for the effect of 5-FU-based chemotherapy. Methylenetetrahydrofolate reductase (MTHFR) plays a role in the metabolism of folate. The gene of MTHFR is polymorphic (C667T, alanine-to-valine), and this is related to the activity of the enzyme. We...

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Source

Identifiers

PMID: 11299748

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11299748-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Methylenetetrahydrofolate reductase polymorphism is associated with folate pool in gastrointestinal cancer tissue.PMID 11299748Read ↗

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