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Article

Methylenetetrahydrofolate reductase polymorphism is associated with folate pool in gastrointestinal cancer tissue.

Anticancer research - 1 Jan 2000

Kawakami K, Omura K, Kanehira E, Watanabe G

Abstract excerpt

The folate pool in cancer tissue is a critical factor for the effect of 5-FU-based chemotherapy. Methylenetetrahydrofolate reductase (MTHFR) plays a role in the metabolism of folate. The gene of MTHFR is polymorphic (C667T, alanine-to-valine), and this is related to the activity of the enzyme. We analyzed the association between MTHFR genotype and the folate pool in gastrointestinal cancer tissues. MTHFR...

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Identifiers

PMID: 11299748

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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