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Article

Dietary folate is associated with p16(INK4A) methylation in head and neck squamous cell carcinoma.

International journal of cancer - 1 Oct 2006

Kraunz Kim S, Hsiung Debra, McClean Michael D, Liu Mei, Osanyingbemi Joyce, Nelson Heather H, Kelsey Karl T

Abstract excerpt

Inactivation of the p16(INK4A) (CDKN2A) gene in the Rb pathway is among the most common somatic alterations observed in tobacco-related solid tumors, including head and neck squamous cell carcinoma (HNSCC). In addition, a low folate diet is an important risk factor for HNSCC. Decreased dietary folate in an animal model of hepatocellular carcinoma has been associated with the induction of epigenetic silencing of...

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Share to Carcinoma, Squamous Cell
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16646054
DOI: 10.1002/ijc.22013

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dietary folate is associated with p16(INK4A) methylation in head and neck squamous cell carcinoma.PMID 16646054Read ↗

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